Road trip guide
Great River Road (Missouri): the drive, the stops and where to sleep
- Distance
- About 120 miles (193 km)
- Time
- 1–2 days
- Best time
- May–October
Mark Twain's Mississippi River towns and bluffs. National Scenic Byway, Little Dixie Highway.
Open this route in XCRSNHighlights
- Mark Twain Boyhood Home
- Lover's Leap
- Lock and Dam 24
The route
- Hannibal, MO
- Louisiana, MO
- Clarksville, MO
Road trip tips
- Check route weather and fuel stops on the Plan tab before you go.
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